Prolonged oestrogen exposure is an established risk factor for developing oestrogen-positive breast cancer. Due to various lifestyle modifications, both male and female infertility is on the rise. However, the significance of extrinsic hormone supplementation as part of fertility treatment and its relationship to the development of breast cancer remains uncertain. 

Here, we discuss three cases of young breast cancer patients who presented within a span of 1 month and all three of them were nulliparous and on treatment with ovarian stimulation drugs. 

In contrast to hormone replacement therapy (HRT), fertility treatments induce transient high levels of circulating oestrogen to initiate ovulation in women with anovulatory disorders and control hyperstimulation in women receiving assisted reproductive technology (ART). This topic is one of on-going research and needs thorough evaluation before we conclude this association.