Dr. Aristida Colan-Georges
County Clinical Emergency Hospital, RomaniaTitle: Positive and differential diagnosis of multiple breast cancer by full breast ultrasonography – An anatomical, non-invasive scanning
Abstract
Breast cancer (BC) is classified by extension into unifocal
and multiple synchronous foci, which include multifocal, multicentric, and
diffuse types (such as inflammatory BC, which may affect one or more lobes of
the breast). Intramammary metastases are extremely rare at the time of imaging
diagnosis and are not the subject of this study. Radiological-imaging diagnosis
and postoperative characterization of multicentric and multifocal tumors depend
on localization in arbitrarily established quadrants, which are illogical for
mammography that considerably deforms the breast by compression in two
non-orthogonal views. Moreover, the orthogonal scans and the same quadrants
were borrowed by classical Ultrasonography and Magnetic Resonance Imaging,
despite the specific anatomical breast architecture represented by 15-25
glandular lobes with radial arrangement around the nipple.
We aim to present and illustrate aspects of multiple BC
using the concept of Full Breast Ultrasonography, which allows anatomical
localization and assessment of extension based on radial and antiradial
scanning around the nipple; an intralobular ductal connection of lesions is
considered for multifocal, usually monoclonal cancers, with the assumption that
a lobe may extend into two adjacent breast quadrants. Localization in different
mammary lobes is an argument for multicentric, pathologically proven
multiclonal cancers, regardless of belonging to mammary quadrants. The
prevalence of multiple BC in our series was around 40%, higher than in MRI
reports. Normal and abnormal lobar architecture is illustrated and sustained by
the “Sick lobe theory” and the “gross section” in pathology promoted by T. Tot.
The differential diagnosis of multifocal from multicentric cancers allows a
personalized oncological treatment, a better choice of conservative or radical
surgical approach, minimization of postoperative local recurrences, and
improved life expectancy.
In conclusion, instead of delimiting the quadrants
established by the BI-RADS system, the lobar criterion is recommended for
assessing the extension and discriminating between unifocal, multifocal, and
multicentric BC.
Biography
Aristida Colan-Georges completed
her Ph.D. at the University of Medicine and Pharmacy in Craiova, Romania
(2006). She holds a Certificate in Advanced Specialized Training from the
University of Pierre and Marie Curie, Paris, France (2005). Her publications
include more than 25 articles, 13 chapters, and 4 monographs in volumes such as
"Atlas of Full Breast Ultrasonography," A. Colan-Georges, Springer
Int. Publisher, 2016, https://doi.org/10.1007/978-3-319-31418-1. Her research
in Breast Ultrasound has been presented as lectures in numerous courses
organized by the Euroson School in Romania since 2004 and by the World
Federation for Ultrasound in Medicine and Biology (WFUMB) in the Republic of
Moldova (2017; 2022). She is an active member of many Radiological-Imaging
Societies, including The European Society of Radiology (ESR) and The European
Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB).
Aristida Colan-Georges is a
promoter of the non-invasive anatomical approach in the diagnosis of breast
pathology, based on radial and antiradial ductal ultrasonography supplemented
with Doppler evaluation and strain Sonoelastography, the new integrative
concept called "Full breast ultrasonography." This technique standardizes
and increases the accuracy of breast ultrasound, providing new diagnostic data
useful for the surgical and oncological treatment of breast lesions.