Management of the breast cancer has multidisciplinary approach including surgery followed by radiotherapy, chemotherapy and / or hormonal therapy. The use of adjuvant locoregional radiotherapy as a component of breast-conserving therapy or after mastectomy has been proven to reduce the risk of local-regional recurrence (LRR) and to improve long-term breast cancer-specific and overall survival. Our study was intended to compare two hypofractionated radiotherapy regimens (one week Fast Forward versus three weeks) in the post-operated early breast cancer patients in terms of locoregional recurrence and toxicities like skin reactions, dysphagia, pneumonitis, Arm edema and shoulder movement. Total 60 Patients of carcinoma breast stage IIA-IIIA (pT1-3, pN0-1) who was treated with post mastectomy or breast conservative surgery (BCS) were included and randomized into two arms, 30 patients in each arm.  Arm A (Study arm) treated with 26 Gy in 5 Fractions (Fast Forward) over 1 week (5 fr per week) and Arm B (Control arm) with 40 Gy in 15 Fractions regimen over 3 weeks (5 fractions per week). Both arms followed up at 1, 3, 6 and 9 months after completion of radiotherapy. Results of study as evident by p value (p=0.049) in grade 1 skin reaction was statistically significant in arm A. The study observed that dysphagia, pneumonitis, arm oedema, range of shoulder movement was not found to be statistically significant in both arm during follow up of radiotherapy at 1st and 3rd week ,1st, 3rd, 6th and 9th month. (26.66% in arm A and 20.00% in arm B). In conclusion both hypo-fractionated arms were comparable in term of efficacy and toxicity. And 1-week course seems to be significantly resource-saving with nearly 66% indirect cost reduction, If radiation is finished in one week as compared to three weeks, the patient compliance would be better.