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Abdalla suliman
Sharjah University, United Arab EmiratesPresentation Title:
A Comprehensive Pan-Cancer Analysis Reveals GRB7 as a Potential Diagnostic and Prognostic Biomarker
Abstract
Background and Aim: Growth factor receptor-bound protein 7 (GRB7) is an adaptor protein involved in cellular signaling pathways regulating growth and differentiation. While its role in cancer is recognized, its diagnostic and prognostic significance remains underexplored. This study aims to assess GRB7’s relevance across multiple cancers.
Materials and Methods: GRB7 expression was analyzed across cancers using TIMER, GEPIA, and UALCAN databases. Correlations with clinicopathological parameters, prognosis, immune infiltration, and genetic alterations were evaluated using Kaplan-Meier plotter, cBioPortal, and the Human Protein Atlas. Findings were validated using the GEO database.
Results: GRB7 was significantly upregulated in multiple cancers, including bladder (BLCA) and cervical (CESC) cancers, while it was downregulated in kidney cancers (KICH, KIRC). Prognostic analysis linked high GRB7 expression to improved survival in KIRC but poorer prognosis in pancreatic cancer (PAAD). Immune infiltration analysis revealed significant correlations, particularly in kidney and pancreatic cancers.
Conclusion: GRB7 holds promise as a diagnostic marker for KICH, a prognostic marker for PAAD, and both a diagnostic and prognostic marker for KIRC. These findings highlight its potential as a biomarker and therapeutic target in oncology.
Biography
Abdalla Suliman has completed his BSc from Al Neelain University, Faculty of Medical Laboratory Sciences, Sudan. He works at the Research Institute at the College of Medicine, University of Sharjah, United Arab Emirates.
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