Dr. Carolyn R. Zalameda-CastroUniversity of the Philippines College of Medicine, Philippines
Title: Clinical profile and survival outcomes of Filipino women with uterine sarcoma: A 10-year retrospective cohort study in a tertiary hospital
BACKGROUND: Uterine sarcoma is a rare kind of gynecologic cancer. This study aimed to determine the prevalence of uterine sarcoma subtypes and determine clinical and demographic characteristics and outcomes of uterine sarcoma.
METHODS: This is a retrospective cohort study of population diagnosed with uterine sarcoma from January 2008 to December 2014. Patient demographic data were obtained and Kaplan Meier survival curves were used to estimate overall survival (OS) and progression free survival (PFS). Multivariate analysis using Cox regression analysis was used to determine the association of PFS and OS with clinically important prognostic factors.
RESULTS: A total of 87 patients diagnosed with uterine sarcoma had median progression free survival of 4 months and median overall survival of 36 months. Histologic subtype, age, tumor size, adjuvant treatment with radiotherapy and chemotherapy showed no significant association with disease progression (p=0.05). It was, however, observed that surgical approach (p= 0.004) and staging (p=0.038) were significantly associated with disease progression.
CONCLUSIONS: The observed 3-year PFS was 41.5% and OS was 61.4%. The median progression free survival was 4 months and median overall survival was 36 months. Multivariate analysis showed that lack of complete surgical staging and advanced stages of the disease were significant predictors of disease progression.
Carolyn R. Zalameda-Castro is a clinical associate professor at the University of the Philippines College of Medicine. She is a consultant of the Division of Gynecologic Oncology of the Department of Obstetrics and Gynecology of the Philippine General Hospital. She is currently a panel member of the University of the Philippines Research Ethics Board Review, the president of the Philippine Society of Cervical Pathology and Colposcopy, board secretary of the Society of Gynecologic Oncologists of the Philippines and the chair of the Task Force on Women First of the Philippine Obstetrical and Gynecological Society. She is also a member of the Asian Society of Gynecologic Oncology Education Committee. She is also a member of the Honorary Editorial Advisory Board for MIMS Oncology. She has 15 research publications and 10 clinical practice guidelines chapter publications.